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From the Program in Occupational Health and Environmental Medicine (M.M. Finkelstein and Verma), the Institute of Environment and Health (M.M. Finkelstein, Jerrett, DeLuca, N. Finkelstein and Verma), the Centre for Spatial Analysis (DeLuca), the Department of Family Medicine (M.M. Finkelstein and Verma), the Health Studies Program, School of Geography and Geology (Jerrett, DeLuca and N. Finkelstein), and the Department of Medicine (Sears), McMaster University, Hamilton, Ont.; and the Departments of Family Medicine and Public Health Sciences (M.M. Finkelstein) and the Department of Medicine (Chapman), University of Toronto, Toronto, Ont.
Correspondence to: Dr. Murray M. Finkelstein, Family Medicine Centre, Ste. 413, Mount Sinai Hospital, Toronto ON M5G 1X5; fax 416 326-7761; murray.finkelstein{at}utoronto.ca
Background: Community levels of air pollution have been associated with variability in mortality rates, but previous studies have inferred exposure to pollutants on a citywide basis. We investigated mortality in relation to neighbourhood levels of income and air pollution in an urban area.
Methods: We identified 5228 people in the HamiltonBurlington area of southern Ontario who had been referred for pulmonary function testing between 1985 and 1999. Nonaccidental deaths that occurred in this group between 1992 and 1999 were ascertained from the Ontario Mortality Registry. Mean household income was estimated by linking the subjects' postal codes with the 1996 census. Mean neighbourhood levels of total suspended particulates and sulfur dioxide were estimated by interpolation from data from a network of sampling stations. We used proportional hazards regression models to compute mortality risk in relation to income and pollutant levels, while adjusting for pulmonary function, body mass index and diagnoses of chronic disease. Household incomes and pollutant levels were each divided into 2 risk categories (low and high) at the median.
Results: Mean pollutant levels tended to be higher in lower-income neighbourhoods. Both income and pollutant levels were associated with mortality differences. Compared with people in the most favourable category (higher incomes and lower particulate levels), those with all other incomeparticulate combinations had a higher risk of death from nonaccidental causes (lower incomes and higher particulate levels: relative risk [RR] 2.62, 95% confidence interval [CI] 1.674.13; lower incomes and lower particulate levels: RR 1.82, 95% CI 1.302.55; higher incomes and higher particulate levels: RR 1.33, 95% CI 1.121.57). Similar results were observed for sulfur dioxide. The relative risk was lower at older ages.
Interpretation: Mortality rates varied by neighbourhood of residence in this cohort of people whose lung function was tested. Two of the broader determinants of health income and air pollution levels were important correlates of mortality in this population.
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