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DEET-based insect repellents: safety implications for children and pregnant and lactating women

From the Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children and University of Toronto, Toronto, Ont. (Koren); the Division of Clinical Pharmacology, Children's Hospital of Western Ontario and University of Western Ontario, London, Ont. (Matsui); and the Divisions of Emergency Medicine and of Clinical Pharmacology and Toxicology, Hôpital Ste-Justine and Université de Montréal, Montréal, Que. (Bailey)

Correspondence to: Dr. Gideon Koren, Division of Clinical Pharmacology, Hospital for Sick Children, 555 University Ave., Toronto ON M5G 1X8; fax 416 813-7562; gkoren{at}sickkids.ca

Abstract

REDUCING THE RISK OF MOSQUITO BITES is currently the only way to reduce the risk of West Nile virus infection. Methods for avoiding mosquito bites include limiting the time spent outdoors at dawn and dusk, wearing protective clothing and using an insect repellent. Repellents containing DEET (N,N-diethyl-m-toluamide, also known as N,N-diethyl-3-methylbenzamide) are the most effective and most widely used. However, concerns have been raised over the risk of adverse toxic effects, especially in young children and pregnant and lactating women. In this article, we review the available evidence on the effectiveness and safety of DEET-based products. The evidence does not support increased risk in young children.

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