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CMAJ • March 18, 2003; 168 (6)
© 2003 Canadian Medical Association or its licensors

Research
Recherche

Knowledge and attitudes of pregnant women with regard to collection, testing and banking of cord blood stem cells

Conrad V. Fernandez, Kevin Gordon, Michiel Van den Hof, Shaureen Taweel and Françoise Baylis

From the Department of Pediatrics (Fernandez, Gordon), the Department of Obstetrics and Gynecology (Van den Hof) and the Department of Bioethics (Baylis), Dalhousie University, and the IWK Health Centre (Taweel), Halifax, NS

Correspondence to: Dr. Conrad Fernandez, IWK Health Centre, PO Box 3070, 5850 University Ave., Halifax NS B3J 3G9; fax 902 470-7216; conrad.fernandez{at}iwk.nshealth.ca

Background: Umbilical cord blood is used as a source of hematopoietic stem cells for bone marrow transplantation in the treatment of malignant and nonmalignant disease. We sought to examine pregnant women's knowledge and attitudes regarding cord blood banking, as their support is crucial to the success of cord blood transplant programs.

Methods: A questionnaire examining sociodemographic factors and women's attitudes to cord blood banking was developed on the basis of findings from 2 focus groups and a pilot study. The questionnaire was distributed to 650 women attending antenatal clinics at a regional women's hospital between April and July 2001.

Results: A total of 443 women (68%) responded. More than half of the women (307/438 or 70% [95% confidence interval, CI, 66% to 74%]) reported poor or very poor knowledge about cord blood banking. Many of the respondents (299/441 or 68% [95% CI 63% to 72%]) thought that physicians should talk to pregnant women about the collection of cord blood, and they wanted to receive information about this topic from health care professionals (290/441 or 66% [95% CI 61% to 70%]) or prenatal classes (308/441 or 70% [95% CI 65% to 74%]). Most of the women (379/442 or 86% [95% CI 82% to 89%]) would elect to store cord blood in a public bank, many citing altruism as the reason for this choice. A much smaller proportion (63/442 or 14% [95% CI 11% to 18%]) would elect private banking, indicating that this would be a good investment or that they would feel guilty if the blood had not been stored. Additional acceptable uses for cord blood included research (mentioned by 294/436 women or 67% [95% CI 63% to 72%]) and gene therapy (mentioned by 169/437 women or 39% [95% CI 34% to 43%]).

Interpretation: Most of the women in this study supported the donation of cord blood to public cord blood banks for potential transplantation and research.




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