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CMAJ • March 4, 2003; 168 (5)
© 2003 Canadian Medical Association or its licensors

Review
Synthèse

Diagnosis and management of Graves' disease

Jody Ginsberg

Dr. Ginsberg is with the Division of Endocrinology and Metabolism, Heritage Medical Research Centre, University of Alberta, Edmonton, Alta.

Correspondence to: Dr. Jody Ginsberg, Rm. 362, Heritage Medical Research Centre, University of Alberta, 152 University Campus NW, Edmonton AB T6G 2S2; fax 780 492-7137; jody.ginsberg{at}ualberta.ca

Abstract

GRAVES' DISEASE IS CHARACTERIZED BY HYPERTHYROIDISM, diffuse goitre, ophthalmopathy and, rarely, dermopathy. Although diagnostic testing is straightforward once Graves' disease is suspected, physicians need to be aware of heterogeneous and even atypical presentations of the disease, particularly in elderly patients. Because morbidity may be associated with even subtle forms of hyperthyroidism, treatment promoting long-term euthyroidism is necessary. Although all of the available treatments are effective, compliance is best assured by a full discussion of the risks and benefits of each approach. This review focuses on issues of diagnosis and management that will allow the primary care physician to identify patients with Graves' disease and guide them to recovery.




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