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CMAJ • March 4, 2003; 168 (5)
© 2003 Canadian Medical Association or its licensors

Research
Recherche

Case report

Severe hydrocephalus associated with congenital varicella syndrome

Massimo Mazzella, Cesare Arioni, Carlo Bellini, Anna Elsa Maria Allegri, Cesarina Savioli and Giovanni Serra

From the Servizio di Patologia Neonatale, Dipartimento di Pediatria, Università di Genova, Istituto Giannina Gaslini (Mazzella, Arioni, Bellini, Allegri, Serra), and the Servizio di Anatomia Patologica, Istituto Giannina Gaslini (Savioli), Genoa, Italy.

Correspondence to: Dr. Carlo Bellini, Servizio di Patologia Neonatale, Dipartimento di Pediatria, Università di Genova, Istituto Giannina Gaslini, Largo G. Gaslini, 5, 16147 Genova, Italia; fax 39 010 3770675; carlobellini{at}ospedale-gaslini.ge.it

CONGENITAL VARICELLA SYNDROME refers to the spectrum of fetal anomalies associated with maternal varicella zoster virus (VZV) infection during the first trimester of pregnancy. The syndrome is rare and the risk to the fetus uncertain. We describe an unusual case of congenital varicella syndrome in which hydrocephalus was the main consequence and likely represented VZV reactivation in utero.


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