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CMAJ • March 20, 2001; 164 (6)
© 2001 Canadian Medical Association or its licensors

Review
Synthèse

Addiction and the brain: the role of neurotransmitters in the cause and treatment of drug dependence

Denise M. Tomkins*{dagger} and Edward M. Sellers*{dagger}{ddagger}§

From *the Centre for Addiction and Mental Health, Toronto, Ont.; the Departments of {dagger}Pharmacology, {ddagger}Medicine and §Psychiatry, University of Toronto, Toronto, Ont; and ¶the Centre for Research in Women's Health, Sunnybrook & Women's College Health Sciences Centre, Toronto, Ont.

Abstract

RECENT SCIENTIFIC ADVANCES HAVE LED to a greater understanding of the neurobiological processes that underlie drug abuse and addiction. These suggest that multiple neurotransmitter systems may play a key role in the development and expression of drug dependence. These advances in our knowledge promise not only to help us identify the underlying cause of drug abuse and dependence, but also to aid the development of effective treatment strategies.




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