Advertisement
ADVANCED SEARCH

This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hill, M. D. Articles by Buchan, A. M. Search for Related Content PubMed PubMed Citation Articles by Hill, M. D. Articles by Buchan, A. M. Related Collections Allergy Drugs: central nervous system (not psychiatric) Stroke

Anaphylactoid reactions and angioedema during alteplase treatment of acute ischemic stroke

From the Department of Clinical Neurosciences, University of Calgary, Calgary, Alta.
Drs. Hill and Buchan received grants from the Medical Research Council of Canada, the Heart and Stroke Foundation of Canada and the Alberta Heritage Foundation for Medical Research. Dr. Feasby is funded by a grant from the Heart and Stroke Foundation of Canada.

Among 105 patients given recombinant tissue plasminogen activator (rt-PA, alteplase) intravenously for acute stroke, 2 (1.9%) had lingual angioedema, which progressed to a fatal anaphylactoid reaction in 1. The authors review the 2 cases and possible mechanisms responsible. They warn that patients who are taking an angiotensin-converting-enzyme inhibitor may be at increased risk for angioedema with concomitant alteplase therapy.

This article has been cited by other articles:

				M. Rucker, T. Schafer, C. Scheuer, Y. Harder, B. Vollmar, and M. D. Menger Local Heat Shock Priming Promotes Recanalization of Thromboembolized Microvasculature by Upregulation of Plasminogen Activators Arterioscler Thromb Vasc Biol, July 1, 2006; 26(7): 1632 - 1639. [Abstract] [Full Text] [PDF]

				M. D. Hill, A. M. Buchan, and for The Canadian Alteplase for Stroke Effectivenes Thrombolysis for acute ischemic stroke: results of the Canadian Alteplase for Stroke Effectiveness Study Can. Med. Assoc. J., May 10, 2005; 172(10): 1307 - 1312. [Abstract] [Full Text] [PDF]

				M. D. Hill, T. Lye, H. Moss, P. A. Barber, A. M. Demchuk, N. J. Newcommon, T. L. Green, C. Kenney, A. Cole-Haskayne, and A. M. Buchan Hemi-orolingual angioedema and ACE inhibition after alteplase treatment of stroke Neurology, May 13, 2003; 60(9): 1525 - 1527. [Abstract] [Full Text] [PDF]

				G. Molinaro, M. Cugno, M. Perez, Y. Lepage, N. Gervais, A. Agostoni, and A. Adam Angiotensin-Converting Enzyme Inhibitor-Associated Angioedema Is Characterized by a Slower Degradation of des-Arginine9-Bradykinin J. Pharmacol. Exp. Ther., October 1, 2002; 303(1): 232 - 237. [Abstract] [Full Text] [PDF]

				G. Molinaro, N. Gervais, and A. Adam Biochemical Basis of Angioedema Associated With Recombinant Tissue Plasminogen Activator Treatment: An In Vitro Experimental Approach Stroke, June 1, 2002; 33(6): 1712 - 1716. [Abstract] [Full Text] [PDF]

				M. D. Hill, P. A. Barber, A. M. Demchuk, N. J. Newcommon, A. Cole-Haskayne, K. Ryckborst, L. Sopher, A. Button, W. Hu, M. E. Hudon, et al. Acute Intravenous-Intra-Arterial Revascularization Therapy for Severe Ischemic Stroke Stroke, January 1, 2002; 33(1): 279 - 282. [Abstract] [Full Text] [PDF]

				M. D. Hill, P. A. Barber, J. Takahashi, A. M. Demchuk, T. E. Feasby, and A. M. Buchan Reactions to alteplase in patients with acute thrombotic stroke Can. Med. Assoc. J., August 1, 2000; 163(4): 388 - 389. [Full Text] [PDF]

				W. B. Chodirker Reactions to alteplase in patients with acute thrombotic stroke Can. Med. Assoc. J., August 1, 2000; 163(4): 387 - 388. [Full Text] [PDF]

HOME	CURRENT ISSUE	PAST ISSUES	COLLECTIONS	HELP	SEARCH
Copyright 1995-2000, Canadian Medical Association. All rights reserved. ISSN 1488-2329 (e) 0820-3946 (p) All editorial matter in CMAJ represents the opinions of the authors and not necessarily those of the Canadian Medical Association.